Insilco Analysis of Wolbachia Surface Protein in Wolbachia Endosymbiont of D. Melenogaster

Wolbachia surface protein is a gram negative bacterial membrane protein which participates in host immune response, pathogenesis and controlled cell death programme. The surface protein of the bacterium is highly important because it acts a source for electing strong immunogenic role and development of vaccines. Bio-physical characterization of Wolbachia surface protein is of utmost importance as it would pave way for novel drug designing. The current study employs the bio-informatics tool to unravel the structural and functional properties of the protein. The WSP was predicted to be a β barrel transmembrane protein. The structure was predicted by Homology modeling and Validated by Procheak. The Investigations on WSP in target template sequence alignment reveled 34% homology to Neisseria surface protein (NSP A) and the superimposition of the modeled protein showed highest similarity with OMP of E coli which act as porins; it has shown to work as a channel to transport small compounds across the planar lipid bilayer.

Corresponding author:  Dr.H.P. Puttaraju *

E-mail address:  puttarajuhp@hotmail.com

Citation: Dr.H.P. Puttaraju * (Insilco Analysis of Wolbachia surface protein in Wolbachia endosymbiont of D. melenogaster) BIOMIRROR: 24-29 / bm- 0105081514

Copyright: ©: Dr.H.P. Puttaraju *. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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