Cellular Differentiation Regulate Gene Expression Through DNA-Methylation

Cellular differentiation is a transition of a cell from one cell to another and plays a very important role to regulate the gene expression through DNA methylation including small number of genes such as OCT4 and NANOG are methylated and their promoters repressed to prevent further expression.It is an epigenetic mechanism for the differentiation of pluoripotent stem cells and mammilain cells harbor small ncRNA,snoRNA,miRNA’s, and dsRNA’s associated with gene inactivation that cannot cause gene silencing denovo,but can also be acquired as a consequence of upstream gene downregulation. To find the transcription factor binding sites(TFBS),we fit a classification tree to the data using the CART software in R. The CART method selects a sequence of TFBS that optimally separates the gene classes.The deathbase database participate in extrinsic or intrinsic, pre-mitochondrial signaling events or post-mitochondrial caspase activation and apoptic cell clearance.

Corresponding author: Sheema Sadana*

E-mail address: sheemasadana@yahoo.com

Citation: Sheema Sadana* (Cellular Differentiation Regulate Gene Expression Through DNA-methylation) BIOMIRROR: 12-18 / bm- 0124021014

Copyright: ©: Sheema Sadana*. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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